Organ-specific isolation of hepatocyte extracellular vesicles from human plasma enables tissue-resolved proteomic and miRNA profiling
Ricardo Figueiras, Susana Vagueiro, Raissa G. G. Kay, Elnaz Persia, Roger de Alwis, Razan Hijazi, Brian Ritchie Davidson, Raquel Sanches-Kuiper, Pierre Arsène, Tomás Dias
The paper develops NEXPLOR, a method to isolate hepatocyte-derived extracellular vesicles from plasma, enabling tissue-resolved proteomic and miRNA profiling for liver disease analysis.
bioRxiv · Jun 13, 2025 · PreprintMolecular Biology