CRISPRCas9-mediated gene disruption of endogenous co-receptors confers broad resistance to HIV-1 in human primary cells and humanized mice
Shasha Li, Leo Holguin, John C. Burnett
This study shows that CRISPR/Cas9 disruption of CCR5 and CXCR4 in human cells provides broad HIV-1 resistance but may impair CD4+ T cell engraftment when both co-receptors are targeted.
Molecular Therapy — Methods & Clinical Development · Jan 22, 2022Peer-reviewedMolecular Biology