Author

Leo Holguin

City Of Hope National Medical CenterORCID 0000-0002-8462-187XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

John C. BurnettiD· 2 shared Liliana Echavarria ParraiD· 1 shared Shasha LiiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 2 mutual co-author links

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2 shared papersMolecular Biology

John C. BurnettORCID

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2 papers

Recent·Most cited

Molecular BiologyMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewedJan 22, 2022

CRISPRCas9-mediated gene disruption of endogenous co-receptors confers broad resistance to HIV-1 in human primary cells and humanized mice

Shasha Li, Leo Holguin, John C. Burnett

This study shows that CRISPR/Cas9 disruption of CCR5 and CXCR4 in human cells provides broad HIV-1 resistance but may impair CD4+ T cell engraftment when both co-receptors are targeted.

35 citations

humanexperimental assay

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Molecular BiologybioRxivPreprintJun 3, 2021

Novel GVHD resistant humanized-PBMC mouse model for preclinical HIV research

Leo Holguin, Liliana Echavarria Parra, John C. Burnett

This paper introduces a novel humanized mouse model resistant to GVHD that supports HIV-1 infection and is valuable for preclinical HIV research.

DOI 10.1101/2021.06.03.446835

mouseexperimental assay

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