Integrating promiscuous enzyme activities in protein-constrained models pinpoints the role of underground metabolism in robustness of metabolic phenotypes
Maurício Alexander de Moura Ferreira, Eduardo Luís Menezes de Almeida, Wendel Batista da Silveira, Zoran Nikoloski
The paper develops a toolbox to model promiscuous enzyme activities in metabolic models, showing that underground metabolism enhances metabolic flexibility and robustness.