Kumiko Ito-Miwa

This study identifies ADP release as the rate-limiting step in the KaiC ATPase cycle and shows how the nucleotide cycle integrates core circadian clock properties in cyanobacteria.

This paper identifies the 322nd residue of KaiC as a third period-tuning site, showing that mutations at this site can alter circadian period length through effects on ATPase activity.

The paper investigates the evolutionary origin of self-sustained Kai protein circadian oscillators in cyanobacteria by analyzing ancestral Kai proteins and their functional and structural development.