Higher-Order Interactions in Neuronal Function: From Genes to Ionic Currents in Biophysical Models
Maria Reva, Alexis Arnaudon, Mickaël Zbili, Abdullah Makkeh, Henry Markram, Jean‐Marc Goaillard, Werner A. H. Van Geit
This study uses biophysical models and statistical methods to show that neuronal firing patterns depend on synergistic interactions of multiple ionic currents, contrasting with gene expression redundancy observed in single-cell RNAseq data.
Proceedings of the National Academy of Sciences · Sep 29, 2025Peer-reviewedNeuroscience