Maria Reva

Distinct modes of dopamine modulation on striatopallidal synaptic transmission

This study investigates how dopamine modulates striatopallidal synapses in different GPe subregions, revealing region-specific presynaptic and postsynaptic inhibition mechanisms.

A Detailed Model for Understanding the Human Neocortex

This study builds a detailed computational model of the human neocortex and compares it to a rat model, revealing differences in cell density, branching complexity, and synaptic connectivity.

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation

The paper presents a large-scale biophysically detailed model of somatosensory cortex to simulate and validate cortical dynamics and experimental results.

Higher-Order Interactions in Neuronal Function: From Genes to Ionic Currents in Biophysical Models

This study uses biophysical models and statistical methods to show that neuronal firing patterns depend on synergistic interactions of multiple ionic currents, contrasting with gene expression redundancy observed in single-cell RNAseq data.

Controlling morpho-electrophysiological variability of neurons with detailed biophysical models

The paper develops a method to generate populations of detailed biophysical neuron models that reproduce experimental variability using Markov chain Monte Carlo techniques.

A universal workflow for creation, validation and generalization of detailed neuronal models

The paper introduces a workflow for creating and validating detailed neuronal models using rat somatosensory cortex data, showing it can generate models with varied responses.

Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer s disease

This study shows that overexpressing UCP4 in astrocytic mitochondria prevents metabolic and structural neuronal dysfunctions in a mouse model of Alzheimer's disease.

Distinct nanoscale calcium channel and synaptic vesicle topographies contribute to the diversity of synaptic function

The paper investigates the nanoscale arrangement of calcium channels and synaptic vesicles in cerebellar synapses, finding distinct topographies that correlate with synaptic strength and functional diversity.