Author

Georgia B. McGaughey

Vertex Pharmaceuticals (United Kingdom)ORCID 0000-0002-3586-965XUnclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

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Approach:simulation· 1 Approach:statistical model· 1

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Allan C. Powe· 1 shared Jade ShiiD· 1 shared Thomas E. ClevelandiD· 1 shared Vijay S. PandeiD· 1 shared

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2018-2018 · peak 1/yr

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1 shared paperMolecular Biology

Allan C. Powe

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Recent·Most cited

CFTR misfolds during native-centric simulations due to entropic penalties of native state formation

Jade Shi, Thomas E. Cleveland, Allan C. Powe, Georgia B. McGaughey, Vijay S. Pande

This study uses molecular dynamics simulations to show that CFTR misfolds due to entropic penalties, even in wild-type forms, and suggests this contributes to disease in mutants like F508del.

bioRxiv · Jun 28, 2018 · PreprintMolecular Biology