Author

Thomas E. Cleveland

National Institute of Standards and TechnologyORCID 0000-0003-1992-8450Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein sequence· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Abdul S. Yunus· 1 shared Allan C. Powe· 1 shared Bjørn Gunnar Rude VoldborgiD· 1 shared Chen‐Lin Hsieh· 1 shared Eric A. TothiD· 1 shared Frances RocamoraiD· 1 shared Georgia B. McGaugheyiD· 1 shared Jade ShiiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

Abdul S. Yunus

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2 papers

Recent·Most cited

BioengineeringBiotechnology and BioengineeringPeer-reviewedJul 1, 2026

Glycoengineered recombinant alpha1-antitrypsin results in comparable in vitro and in vivo activities to human plasma-derived protein

Frances Rocamora, Chen‐Lin Hsieh, Sanne Schoffelen…·Nathan E. Lewis

This study generates glycoengineered recombinant alpha1-antitrypsin with in vitro and in vivo activities comparable to plasma-derived A1AT, offering a sustainable therapeutic alternative.

4 citations

humanprotein sequence

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Molecular BiologybioRxivPreprintJun 28, 2018

CFTR misfolds during native-centric simulations due to entropic penalties of native state formation

Jade Shi, Thomas E. Cleveland, Allan C. Powe…·Vijay S. Pande

This study uses molecular dynamics simulations to show that CFTR misfolds due to entropic penalties, even in wild-type forms, and suggests this contributes to disease in mutants like F508del.

DOI 10.1101/350074

statistical modelsimulation

𝕏 PostBluesky