C. difficile-associated antibiotics prime the host for infection by a microbiome-independent mechanism.
Jemila C. Kester, Douglas K. Brubaker, Jason G. Velazquez, Charles W. Wright, Douglas A. Lauffenburger, Linda Gay Griffith
This study shows that certain antibiotics increase CDAD risk through host-driven changes, not just microbiome disruption, by impairing mucosal barriers and immune function in human gut models.
bioRxiv · Aug 7, 2019 · PreprintMolecular Biology