Linda Gay Griffith

Interactome-based deep learning and path-level decomposition reveal TGFβ-IFNα competition in MASH

The paper uses a deep learning framework to analyze drug-induced transcriptomics and identifies a four-node module involved in TGFβ-IFNα competition in MASH.

Live-cell transcriptomics with engineered virus-like particles

This paper develops a live-cell transcriptomics method using engineered virus-like particles to capture dynamic gene expression without destroying cells.

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

This paper develops a synthetic hydrogel that enables microvascularization in a microphysiological system for endometriosis research, improving reproducibility and biological fidelity.

A Vascularized Liver Microphysiological System Captures Key Features of Hepatic Insulin Resistance and Monocyte Infiltration

This paper develops a vascularized liver microphysiological system to model hepatic insulin resistance and monocyte infiltration, showing altered metabolism, vascular changes, and immune cell recruitment.

A Microphysiological Model of Progressive Human Hepatic Insulin Resistance

This study uses a human liver microphysiological system to investigate how insulin, glucose, and free fatty acids contribute to hepatic insulin resistance and its reversibility.

Simultaneous Label-free Imaging of Nucleolar Dynamics and Subcellular Metabolic Shifts Across Tissue Contexts

This paper develops a label-free imaging platform to study nucleolar dynamics and metabolic shifts in tissues, revealing NADH depletion under nucleolar stress and progesterone-induced changes in endometrial organoids.

Computational modeling of hormone- and cytokine-dependent proliferation of endometrial cells in 3D co-culture

The paper develops ODE and PDE models to simulate endometrial cell proliferation and interactions in 3D co-cultures under hormone and cytokine conditions.

Systems biology framework for rational design of operational conditions for in vitro / in vivo translation of microphysiological systems

The paper develops a machine learning framework to identify optimal experimental conditions for improving the translatability of microphysiological systems to in vivo contexts, using MAFLD as a case study.

Human Mesofluidic Intestinal Model for Studying Transport of Drug Carriers and Bacteria Through a Live Mucosal Barrier

This paper introduces a human mesofluidic intestinal chip to study transport of drug carriers and bacteria through a live mucosal barrier, revealing mucus dynamics and particle interactions.

A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes

This study identifies thyroid hormone receptor THRB as a key regulator of hepatocyte maturation from human PSCs, showing that T3 treatment enhances gene expression and epigenetic features of mature hepatocytes.

C. difficile-associated antibiotics prime the host for infection by a microbiome-independent mechanism.

This study shows that certain antibiotics increase CDAD risk through host-driven changes, not just microbiome disruption, by impairing mucosal barriers and immune function in human gut models.