Autoencoder-transformed transcriptome improves genotype-phenotype association studies
Qing Li, Jiayi Bian, Janith Weeraman, Zilong Zhang, Albert Leung, Qi-Xuan Ding, Thierry Chekouo, Lang Wu, Jun Yi Yan, Jingjing Wu, Quan Long
The paper introduces AE-TWAS, a method that improves genotype-phenotype association studies by transforming transcriptome data with autoencoders to enhance expression heritability and TWAS performance.
IEEE Transactions on Computational Biology and Bioinformatics · May 9, 2025Peer-reviewedBioinformatics