Author

Jun Yi Yan

University of CalgaryORCID 0000-0002-9786-2170Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Research Focus:GWAS / association mapping· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:fine-mapping· 1

Frequent Co-Authors

Qing LiiD· 3 shared Quan LongiD· 3 shared Jiayi BianiD· 2 shared Aaron S. HoweiD· 1 shared Albert Leung· 1 shared Billie Au· 1 shared Chen CaoiD· 1 shared Cooper Gau· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenetics

Qing LiORCID

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3 papers

Recent·Most cited

Autoencoder-transformed transcriptome improves genotype-phenotype association studies

Qing Li, Jiayi Bian, Janith Weeraman, Zilong Zhang, Albert Leung, Qi-Xuan Ding, Thierry Chekouo, Lang Wu, Jun Yi Yan, Jingjing Wu, Quan Long

The paper introduces AE-TWAS, a method that improves genotype-phenotype association studies by transforming transcriptome data with autoencoders to enhance expression heritability and TWAS performance.

IEEE Transactions on Computational Biology and Bioinformatics · May 9, 2025Peer-reviewedBioinformatics

An expression-directed linear mixed model (edLMM) discovering low-effect genetic variants

Qing Li, Jiayi Bian, Yanzhao Qian, Pathum Kossinna, Cooper Gau, Paul M. K. Gordon, Xiang Zhou, Xingyi Guo, Jun Yi Yan, Jingjing Wu, Quan Long

This paper introduces edLMM, a method that detects low-effect genetic variants using moderate sample sizes, improving missing heritability estimation.

Genetics · Feb 5, 2024Peer-reviewedGenetics

Statistical model integrating interactions into genotype-phenotype association mapping: an application to reveal 3D-genetic basis underlying Autism

Qing Li, Chen Cao, Deshan Perera, Jingni He, Xingyu Chen, Feeha Azeem, Aaron S. Howe, Billie Au, Jun Yi Yan, Quan Long

The paper introduces ILMM, a statistical model that integrates genetic interactions into genotype-phenotype association mapping, revealing 3D-genetic basis of ASD and 3D-eQTLs using whole genome and transcriptome sequencing data.

bioRxiv · Jul 27, 2020 · PreprintGenetics