Author

Lauren J. Donoghue

GenentechORCID 0000-0002-3634-680XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 3 Organism:human· 3 Approach:statistical model· 3 Assay:GWAS summary statistics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Amy Stockwell· 3 shared Ann Millar· 3 shared Ayodeji AdegunsoyeiD· 3 shared Beatriz Guillén‐GuíoiD· 3 shared Brian L. YaspaniD· 3 shared Carl ReynoldsiD· 3 shared Carlos FloresiD· 3 shared CleanUP-IPF Investigators of the Pulmonary Trials Cooperative· 3 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Amy Stockwell

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Genome-wide association study of Idiopathic Pulmonary Fibrosis susceptibility using clinically-curated European-ancestry datasets

Daniel Chin, Tamara Hernández-Beeftink, Lauren J. Donoghue, Beatriz Guillén‐Guío, Olivia C. Leavy, Ayodeji Adegunsoye, Helen Booth, CleanUP-IPF Investigators of the Pulmonary Trials Cooperative, William A. Fahy, Tasha E. Fingerlin, Bibek Gooptu, Ian P. Hall, Simon Paul Hart, Mike R. Hill, Nik Hirani, , Louise V. Wain

This study identifies three novel genetic signals associated with idiopathic pulmonary fibrosis using GWAS and clinically-curated datasets, highlighting potential drug targets like MUC1 and NTN4.

European Respiratory Journal · May 21, 2026Peer-reviewedGenetic & Genomic Medicine

Contribution of dominant and recessive model effects to the genetic architecture of Idiopathic Pulmonary Fibrosis

Tamara Hernández-Beeftink, Lauren J. Donoghue, Abril G. Izquierdo, Samuel T Moss, Daniel Chin, Beatriz Guillén‐Guío, Konain Fatima Bhatti, Simon Cameron Biddie, Nick R. G. Shrine, Richard J. Packer, Ayodeji Adegunsoye, Helen Booth, CleanUP-IPF Investigators of the Pulmonary Trials Cooperative, William A. Fahy, Tasha E. Fingerlin, , Louise V. Wain

This study performs GWAS of IPF using dominant and recessive models, identifying five new genome-wide significant signals and genes, including PMF1 and EPN3, and observing increased PMF1 expression in IPF patients.

medRxiv · Feb 19, 2026 · PreprintGenetic & Genomic Medicine

Association study of human leukocyte antigen (HLA) variants and idiopathic pulmonary fibrosis

Beatriz Guillén‐Guío, Megan L. Paynton, Richard J. Allen, D Chin, Lauren J. Donoghue, Amy Stockwell, Olivia C. Leavy, Tamara Hernández-Beeftink, Carl Reynolds, Paul Cullinan, Fernando J. Martínez, CleanUP-IPF Investigators of the Pulmonary Trials Cooperative, Helen Booth, William A. Fahy, Ian P. Hall, , Edward J. Hollox

This study investigates the association between HLA genetic variants and IPF risk using a meta-analysis of seven case-control studies, finding no consistent HLA region associations.

ERJ Open Research · Dec 21, 2023Peer-reviewedGenetic & Genomic Medicine