Bibek Gooptu

This study identifies three novel genetic signals associated with idiopathic pulmonary fibrosis using GWAS and clinically-curated datasets, highlighting potential drug targets like MUC1 and NTN4.

This study shows that both terminal misfolding and polymerisation of Z 1-antitrypsin contribute to liver disease phenotypes, with terminal misfolding driving pro-fibrotic responses and metabolic changes.

The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.

This paper investigates how galectin-3 enhances TGF-β1 activation and signaling in lung fibroblasts, contributing to idiopathic pulmonary fibrosis.