Author

Flavia C. M. Zacconi

Pontificia Universidad Católica de ChileORCID 0000-0002-3676-0453Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Ahad A. RahimiD· 1 shared Amy F. GeardiD· 1 shared Andrew McGowniD· 1 shared Aransa GriñéniD· 1 shared Ben A. MeineniD· 1 shared César A. Ramírez‐SarmientoiD· 1 shared Chiara Pojani· 1 shared Chris DadswelliD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

Ahad A. RahimORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BioengineeringACS Sustainable Chemistry & EngineeringPeer-reviewedSep 14, 2026

MPNN-guided redesign of PET hydrolases with enhanced catalytic activity below the PET glass transition temperature

Aransa Griñén, Valeria Eltit-Villarroel, Francisca Durán-Osorio…·César A. Ramírez‐Sarmiento

This paper redesigns PET hydrolase PHL7 using MPNN models to enhance its catalytic activity at lower temperatures, achieving efficiency comparable to its activity at higher temperatures.

DOI 10.1021/acssuschemeng.6c03808

protein sequencedeep learning

Pharmacology & ToxicologyBiochemical PharmacologyPeer-reviewedSep 11, 2026

A novel pipeline for the validation of manganese chelators for the treatment of manganese overload

Hendrik Vogt, Chiara Pojani, Jack Devonport…·Karin Tuschl

This paper develops a pipeline to identify and evaluate novel manganese chelators using zebrafish and mouse models, finding that H3PyC3A and Me3PyC3A show improved manganese mobilization and reduced accumulation.

1 citation

zebrafishmouse