Kwanghwan Lee

Systematic Growth Factor Profiling Platform for 3D Tumor Models Reveals Estradiol-Responsive Cellular Mechanisms of Immunotherapy Resistance

The paper develops a 3D tumor model platform with growth factor profiling to identify estradiol-responsive cellular mechanisms of immunotherapy resistance in ovarian cancer.

A Co-essentiality Network of Cancer Driver Genes Better Prioritizes Anticancer Drugs

The paper constructs a co-essentiality network from CRISPR screens to prioritize anticancer targets and predict drug responses, outperforming conventional networks in drug repurposing.

Identification of neuron-glia signaling feedback in human schizophrenia using patient-derived, mix-and-match forebrain assembloids

This study uses patient-derived forebrain assembloids to identify neuron-glia signaling feedback abnormalities in schizophrenia, revealing stage-specific developmental mechanisms.

Link clustering explains non-central essential genes in protein interaction networks

The paper identifies link clustering as a principle explaining non-central essential genes in PPI networks, showing they have distinct functional and evolutionary characteristics compared to central essential genes.