Author

Zhongyang Lin

Technion – Israel Institute of TechnologyORCID 0000-0002-3718-6764Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Dvir AraniD· 3 shared Almog Angel· 1 shared Assaf C. BesteriD· 1 shared Carolina Khoury· 1 shared Jürgen C. Becker· 1 shared Michal Brunwesser· 1 shared Mitalee ChandraiD· 1 shared Nalini SrinivasiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

Dvir AranORCID

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3 papers

Recent·Most cited

Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor Therapy

Zhongyang Lin, Mitalee Chandra, Nalini Srinivas, Selma Ugurel, Jürgen C. Becker, Dvir Aran

The paper maps treatment-associated changes in the tumor immune microenvironment using single-cell RNA sequencing and identifies transition patterns that predict response to checkpoint inhibitor therapy.

Cancer Cell · Sep 1, 2026Peer-reviewedCancer Biology

Paralogous lncRNAs CYTOR and MORRBID share a conserved trans acting function in MEK ERK signaling

Tahleel Ali-Nasser, Carolina Khoury, Susie Altalef Mishaan, Ornit Bhonkar, Zhongyang Lin, Youfen Qian, Nisrine Lahoud-Jeries, Dvir Aran, Assaf C. Bester

The paper shows CYTOR and MORRBID lncRNAs share a conserved trans-acting function in MEK-ERK signaling, despite transcriptional divergence.

bioRxiv · Jul 24, 2026 · PreprintGenetics

Predicting Immunotherapy Response Through Chemotherapy-Induced Tumor Microenvironment Remodeling

Almog Angel, Zhongyang Lin, Michal Brunwesser, Dvir Aran

This paper identifies a 50-gene transcriptomic signature that predicts immunotherapy response specifically in patients who receive chemotherapy first, showing treatment-context specificity not seen in existing biomarkers.

bioRxiv · Jun 11, 2026 · PreprintCancer Biology