Author

Nalini Srinivas

German Cancer Research CenterORCID 0000-0002-6899-0800Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Hoewner· 1 shared Alexander RoeschiD· 1 shared Alpaslan TasdoganiD· 1 shared Annette PascheniD· 1 shared Barbara T. GrünwaldiD· 1 shared Batool Shannan· 1 shared Björn ScheffleriD· 1 shared Daniel E. HoffmanniD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Hoewner

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4 papers

Recent·Most cited

Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor Therapy

Zhongyang Lin, Mitalee Chandra, Nalini Srinivas, Selma Ugurel, Jürgen C. Becker, Dvir Aran

The paper maps treatment-associated changes in the tumor immune microenvironment using single-cell RNA sequencing and identifies transition patterns that predict response to checkpoint inhibitor therapy.

Cancer Cell · Sep 1, 2026Peer-reviewedCancer Biology

Spatial Compartmentalization of TCR Repertoires Between Primary Melanomas and Sentinel Lymph Nodes Reveals Distinct Clonal Architectures and Shared Antigen Recognition

Simo Kitanovski, Nalini Srinivas, David Schrama, Daniel E. Hoffmann, Jürgen Christian Becker

The paper analyzes TCR repertoires in melanoma tumors and sentinel lymph nodes to reveal distinct clonal architectures and shared antigen recognition patterns.

bioRxiv · Jul 8, 2026 · PreprintCancer Biology

Redirecting resistance evolution in BRAFV600 melanoma by inhibition of the peroxiredoxin-thioredoxin system

Stefanie Egetemaier, Heike Chauvistré, Renáta Váraljai, Yichao Hua, Smiths Lueong, Samira Makhzami, Nalini Srinivas, Jan Förster, Vivien Ullrich, Simone Stupia, Valéria Schroeder, Sarah Scharfenberg, A. Hoewner, Batool Shannan, Jens Thomas Siveke, , Alexander Roesch

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

bioRxiv · Mar 10, 2025 · PreprintCancer Biology

Telomere length, arsenic exposure and risk of basal cell carcinoma of skin

Nalini Srinivas, P. Sivaramakrishna Rachakonda, Thomas Hielscher, Silvia Calderazzo, Péter Rudnai, Eugen Stelian Gurzau, Kvetoslava Koppová, Tony Fletcher, Rajiv Kumar

The paper investigates the association between telomere length, arsenic exposure, and risk of basal cell carcinoma, finding a synergistic effect in high exposure and short telomere groups.

Carcinogenesis · Mar 12, 2019Peer-reviewedGenetics