Author

Lei Yu

Hong Kong University of Science and TechnologyORCID 0000-0002-3740-7651Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Lei Yu8 papers · The University of Texas Southwestern Medical Center

Biology Disciplines

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Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:graph neural network· 1 Organism:human· 1 Assay:protein structure· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Ali M. FarhatiD· 1 shared Angela Ruohao WuiD· 1 shared Boshen WangiD· 1 shared Bowei YeiD· 1 shared J C LiangiD· 1 shared Lin Xu· 1 shared Xinlei WangiD· 1 shared Xinlei WangiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 22 mutual co-author links

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1 shared paperBioinformatics

Ali M. FarhatORCID

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2 papers

Recent·Most cited

G-SPRI: A Structure-Centric Graph Model for Comprehensive Prediction of Cancer Driver Events from Missense Mutations

Boshen Wang, Ali M. Farhat, Bowei Ye, J C Liang, Lei Yu, Zeyu Lu, Xinlei Wang, Lin Xu

G-SPRI predicts cancer driver events from missense mutations by integrating structural and mutation-specific features using a graph model.

bioRxiv · May 11, 2026 · PreprintBioinformatics

Effect of methanol fixation on single-cell RNA sequencing data

Xinlei Wang, Lei Yu, Angela Ruohao Wu

This study evaluates the impact of methanol fixation on scRNA-seq data, showing it preserves biological signals but introduces subtle biases dependent on library construction methods.

BMC Genomics · Jun 5, 2021Peer-reviewedGenetics