Lin Xu

Extrachromosomal Circular DNA Function as Mobile Elements to Alter the Mammalian Germline Genome

This study shows that extrachromosomal circular DNA (eccDNA) in the male germline can integrate into the genome and contribute to structural variations, with diabetes increasing eccDNA levels in sperm.

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

DeMoP: A Language-Model-Guided Mixture-of-Experts Framework for Cancer Prognosis

DeMoP uses a language-model-guided mixture-of-experts framework to improve cancer prognosis by integrating clinical and molecular data across cohorts.

ApoE4 Promotes Thrombosis via Endothelial Cell ApoER2 and PP2A Activation

This study identifies APOE4 as a risk factor for thrombosis by promoting vWF secretion through ApoER2 and PP2A activation in endothelial cells, leading to increased thrombosis in mice and human veins.

Coronary Artery Disease Transcriptomics Reveals Two Drivers of the Endothelial Cell SR-BI Expression and LDL Transport that Underlie Atherosclerosis

This study identifies two factors, hypercholesterolemia and disturbed blood flow, that upregulate endothelial SR-BI to drive LDL transport and atherosclerosis.

G-SPRI: A Structure-Centric Graph Model for Comprehensive Prediction of Cancer Driver Events from Missense Mutations

G-SPRI predicts cancer driver events from missense mutations by integrating structural and mutation-specific features using a graph model.

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2

The paper predicts T cell and B cell immunogenic epitopes of SARS-CoV-2 using genomic data and compares them with SARS-CoV and MERS-CoV to identify immune vulnerability patterns.

Forward-reverse mutation cycles between stages of cancer development

The paper identifies forward-reverse mutation cycles in cancer development by analyzing LOHs and GOHs across non-tumor, paratumor, and tumor tissues in multiple cancer types.