Author

Zeinab Hamzé

InsermORCID 0000-0002-3753-1038Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Nathalie Bernard‐MarissaliD· 3 shared Nathalie Roëckel· 3 shared Valérie DelagueiD· 3 shared André MégarbanéiD· 2 shared Camille Humbert· 2 shared Christel Castro· 2 shared Karine BertauxiD· 2 shared Nathalie Bonello‐PalotiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Nathalie Bernard‐MarissalORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Gene therapy-mediated overexpression of wild-type MFN2 improves Charcot-Marie-Tooth disease type 2A

Marine Tessier, Zeinab Hamzé, Nathalie Bonello‐Palot, Nathalie Roëckel, Shahram Attarian, Marc Bartoli, Valérie Delague, Bernard Laurent Schneider, Nathalie Bernard‐Marissal

This study shows that overexpressing wild-type MFN2 via gene therapy improves CMT2A in mice, restoring ER-mitochondria contacts and motor function even after symptom onset.

bioRxiv · Oct 15, 2025 · PreprintNeuroscience

Bi-allelic mutations in KCTD11 cause a new form of autosomal recessive intermediate Charcot-Marie-Tooth disease

Jihane Gadacha, Zahraa Haidar, Nathalie Roëckel, Amandine Pauset, Christel Castro, Coralie Provost, Zeinab Hamzé, Camille Humbert, Karine Bertaux, Nicolas Lenfant, Marion Masingue, Alix de Becdelièvre, Marina Konyukh, Nathalie Bonello‐Palot, Anne‐Sophie Lia, , Valérie Delague

This paper identifies bi-allelic mutations in KCTD11 as a cause of autosomal recessive intermediate Charcot-Marie-Tooth disease and elucidates its role in myelin homeostasis through molecular mechanisms.

bioRxiv · Jun 30, 2025 · PreprintGenetics

Altered NRG1/ErbB4 signaling and cholesterol metabolism dysregulation are key pathomechanisms in VRK1-related motor neuropathies and motor neuron diseases

Zeinab Hamzé, Camille Humbert, Khalil Rihan, Nathalie Roëckel, Christel Castro, Nicolas Lenfant, Catherine Aubert, Karine Bertaux, Rosette A. Jabbour, Nathalie Bernard‐Marissal, André Mégarbané, Valérie Delague

The paper investigates VRK1-related motor neuropathies using hiPSC-MNs and bulk mRNA-Seq, identifying altered NRG1/ErbB4 signaling and cholesterol metabolism dysregulation as key pathomechanisms.

bioRxiv · Feb 19, 2024 · PreprintGenetics