Bernard Laurent Schneider

The paper identifies a frequent undesired insertional mutagenesis event during CRISPR/Cas9 HDR-based genome editing in Drosophila and proposes a solution to detect and exclude affected animals.

This study shows that mifepristone, a glucocorticoid antagonist, improves SMA disease phenotypes in mice, both alone and when combined with SMN gene therapy.

This study shows that overexpressing wild-type MFN2 via gene therapy improves CMT2A in mice, restoring ER-mitochondria contacts and motor function even after symptom onset.

This paper shows that NATO3 protects dopaminergic neurons in mouse and human Parkinson's disease models by enhancing autophagy and clearing alpha-synuclein.

Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.

This study shows that FGF4 reduces ALS astrocyte reactivity but fails to protect motor neurons in a mouse model, while TNF exacerbates astrocyte dysfunction.

This study shows Fas activation induces both death and axonal growth in motoneurons, with distinct molecular pathways involved in each response.

This study shows that Mfn2 in NAc D2-MSNs regulates social dominance and neuronal function, while D1-MSNs show transient effects on competitiveness.

The paper introduces the Tabulae Paralytica, a multimodal atlas of spinal cord injury, revealing biological principles and developing a gene therapy to restore walking in old mice.

This study identifies K27 as a critical residue for GDL toxicity and prion-related neurodegeneration using ex vivo reverse genetics in PrPC-deficient slices.

The paper compares IV and ICV delivery of AAV9-SMN in SMA mice, showing different SMN restoration patterns and treatment outcomes.

This study shows that PARKIN levels affect METH self-administration in rats, with lower levels increasing drug-taking behavior and higher levels reducing it.

This study shows that CSP reduces synuclein aggregates and restores dopamine release in a Parkinson's disease mouse model.