Proliferation maintains the undifferentiated status of stem cells: the role of the planarian cell cycle regulator Cdh1
Yuki Sato, Yoshihiko Umesono, Yoshihito Kuroki, Kiyokazu Agata, Chikara Hashimoto
The paper shows that cell cycle arrest is necessary for stem cell differentiation in planarians, as inhibiting Cdh1 disrupts tissue homeostasis and regeneration.
Developmental Biology · Dec 16, 2021Peer-reviewedDevelopmental Biology