The gamma-butyrolactone receptors ScbR and AtrA form a quorum sensing switch between coelimycin and actinorhodin synthesis in Streptomyces coelicolor A3(2)
Bartosz Bednarz, Magdalena Kotowska, Mateusz Wenecki, Michał Tracz, Marta Derkacz, Adrianna Jastrzemska, Jarosław Ciekot, Lizaveta Karpovich, Krzysztof Pawlik
The paper identifies AtrA as a GBL receptor that activates coelimycin production while repressing actinorhodin, revealing a quorum sensing mechanism for antibiotic synthesis in Streptomyces coelicolor.
mBio · Apr 15, 2026Peer-reviewedMolecular Biology