Single-cell atlas reveals alveolar macrophage-specific Oncostatin-M drives pulmonary fibrosis via fibroblast activation in PCV2d infection
Jingmei Xu, Xinyi Fan, Panlong Chen, Yumei Yuan, Yunlong Chen, Gang Fan, Bin Yang, Fan Yang, Yan Wang, Shiqiang Zhang
The paper identifies alveolar macrophage-specific oncostatin M as a driver of pulmonary fibrosis in PCV2d infection and shows targeting it reduces fibroblast activation.
bioRxiv · Dec 10, 2025 · PreprintGenomics