The TMEM16A Channel Mediates the fast polyspermy block in Xenopus Laevis
Katherine L. Wozniak, Wesley A. Phelps, Maiwase Tembo, Miler T. Lee, Anne E. Carlson
The paper identifies TMEM16A as the Ca2+-activated Cl- channel responsible for the fast block to polyspermy in Xenopus laevis eggs by showing that its inhibition reduces fertilization-evoked depolarization.
The Journal of General Physiology · Jul 16, 2018Peer-reviewedDevelopmental Biology