Author

Alessandro Senes

University of Wisconsin–MadisonORCID 0000-0002-3807-2275Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Emma M. CushmaniD· 1 shared Gilbert J. LoiseauiD· 1 shared Joshua ChoiiD· 1 shared Megan LeanderiD· 1 shared Samantha M. AndersoniD· 1 shared Srivatsan RamaniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 10 mutual co-author links

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1 shared paperBiophysics

Emma M. CushmanORCID

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2 papers

Recent·Most cited

BiophysicsBiophysical JournalPeer-reviewedSep 25, 2025

Packing of apolar amino acids is not a strong stabilizing force in transmembrane helix dimerization.

Gilbert J. Loiseau, Alessandro Senes

The paper designs and tests transmembrane helix dimers to assess if apolar side chain packing and van der Waals interactions are sufficient for stabilizing dimerization, finding they are weak unless highly optimized.

3 citations

E. coliprotein structure

𝕏 PostBluesky

BiophysicsPNAS NexusPeer-reviewedSep 23, 2025

High-throughput discovery of transmembrane helix dimers from human single-pass membrane proteins with TOXGREEN sort-seq

Samantha M. Anderson, Joshua Choi, Emma M. Cushman…·Alessandro Senes

This study introduces TOXGREEN sort-seq to measure transmembrane helix oligomerization in large libraries, validating twelve dimer interfaces in human single-pass membrane proteins.

3 citations

humanscRNA-seq

𝕏 PostBluesky