Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
Xin Hu, Marcos R. Estecio, Runzhe Chen, Alexandre Reuben, Linghua Wang, Junya Fujimoto, Jian Carrot‐Zhang, Nicholas McGranahan, Lisha Ying, Junya Fukuoka, Chi-Wan B. Chow, Hoa Hoang Ngoc Pham, Myrna C.B. Godoy, Brett W. Carter, Carmen Behrens, , Jianjun J. Zhang
This study examines DNA methylation changes and intra-tumor heterogeneity in lung adenocarcinoma progression, finding increased methylation aberrations and immunosuppression in later-stage lesions.
Nature Communications · Jan 29, 2021Peer-reviewedGenetic & Genomic Medicine