Jian Carrot‐Zhang

SLC25A28 is a synthetic lethal vulnerability in nucleotide excision repair-deficient cancers

This study identifies SLC25A28 as a synthetic lethal target in NER-deficient cancers, showing its loss impairs cell viability and increases oxidative stress.

Integrated Clinicogenomic Risk Modeling for Metachronous Second Primary Cancers

The paper develops and validates a clinicogenomic risk model to predict second primary cancers in cancer survivors using genetic, clinical, and lifestyle factors.

Meta-Analysis of Rare Cancers Leveraging Clinically Ascertained Cohorts Reveals Novel Germline Susceptibility Loci

This study performs GWAS on 20 rare cancers using three cohorts, identifying nine novel susceptibility loci with replication across eight cancer types.

Dynamic clustering of genomics cohorts beyond race, ethnicity--and ancestry

The paper introduces a dynamic clustering approach for genomics cohorts based on trait-specific genomic signals, revealing patterns beyond predefined racial or continental categories.

Patterns of Structural Variation Define Prostate Cancer Across Disease States

This study identifies distinct structural variation patterns in prostate cancer across disease states, defining clinically actionable subgroups based on whole genome profiling.

Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma

The paper develops DNA- and RNA-based models combining immune and tumor features to predict outcomes of checkpoint inhibition in melanoma.

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

This study examines DNA methylation changes and intra-tumor heterogeneity in lung adenocarcinoma progression, finding increased methylation aberrations and immunosuppression in later-stage lesions.