Deciphering the evolutionary origin of the stereoselectivity of short-chain dehydrogenases in the oxidation of the monoterpenol 1-borneol
Jasmin Zuson, Carl P. O. Helmer, Bruno Di Geronimo, Andrea M. Chánique, Katarína Kavčiaková, Rosa Teijeiro-Juiz, Sebastian Brickel, Nuria Ramirez Molina, Ivana Drienovská, Daniel Kracher, Eric A. Gaucher, Shina Caroline Lynn Kamerlin, Bernhard Loll, Robert Kourist
The paper investigates how natural evolution creates enantioselectivity in plant borneol dehydrogenases through ancestral sequence reconstruction and simulations.
Nature Communications · Aug 14, 2026Peer-reviewedBiochemistry