Nikki Gillum Posnack

Functional Assessment and Extended Culture of Human Pediatric Cardiac Tissue Slices for Preclinical Testing

This study develops a method to culture human pediatric cardiac tissue slices for extended periods, enabling functional and pharmacological testing of cardiac physiology.

Postnatal Development Shapes the Cardiac Response to Milrinone

This study examines how postnatal development affects the cardiac response to milrinone in guinea pig hearts, finding age-dependent variations in chronotropic, inotropic, and lusitropic effects.

Patient-Specific Heart Rate Modulates Developmental Electrophysiology in Transcriptomic-Guided In Silico Models of Pediatric Human Atrial Cardiomyocytes

This study integrates patient-specific heart rates into computational models of pediatric atrial cardiomyocytes to show how developmental changes and pacing rates jointly influence electrophysiological biomarkers.

Chamber-Specific Transcriptomic Insight into Cardiac Development using Guinea Pig and Human Heart Tissue

This study characterizes age- and chamber-specific gene expression patterns in guinea pig and human hearts, identifying conserved maturation markers to support guinea pigs as a preclinical model for pediatric cardiology.

Validation of a Demography-Based Adaptive QTc Formula using Pediatric and Adult Datasets Acquired from Humans and Guinea Pigs

This study introduces and validates an adaptive QTc formula (QTcAd) that adjusts for age demographics, showing improved performance across human and guinea pig age groups compared to existing formulas.

Connecting Transcriptomics with Computational Modeling to Reveal Developmental Adaptations in the Human Pediatric Myocardium

This study analyzes age-dependent gene expression and electrophysiological changes in pediatric patients with congenital heart disease using computational modeling.