Seth H. Weinberg

This study identifies 14-3-3 and S460 as critical for beta-adrenergic regulation of Nav1.5 at the cardiac intercalated disc, enhancing conduction velocity under sympathetic stimulation.

This study integrates patient-specific heart rates into computational models of pediatric atrial cardiomyocytes to show how developmental changes and pacing rates jointly influence electrophysiological biomarkers.

This paper develops a novel cardiomyocyte pair model to quantify gap junction and ephaptic contributions to electrical conduction, showing that ephaptic mechanisms dominate at physiological sodium levels.

This study investigates how hypernatremia affects action potential duration in a mouse model of long QT syndrome type 3, finding that it increases transient outward potassium currents and alters repolarization patterns.

This study develops a computational model of calcium homeostatic feedback to simulate atrial fibrillation progression from healthy to remodeled tissue.

This study analyzes age-dependent gene expression and electrophysiological changes in pediatric patients with congenital heart disease using computational modeling.

The paper introduces iCLEM, a pipeline that correlates multiscale structural data from different imaging modalities using intrinsic fiducials, enabling structure-function relationship discovery.