Inheritance bias of deletion-harbouring mtDNA in yeast: the role of copy number and intracellular selection
Nataliia D. Kashko, Georgii Muravyov, Iuliia E. Karavaeva, Elena S. Glagoleva, Maria D. Logacheva, Sofya K. Garushyants, Дмитрий Алексеевич Кнорре
The paper investigates how mtDNA deletion variants (rho-) outcompete wild-type mtDNA (rho+) in yeast, finding higher copy numbers and intracellular fitness advantage contribute to biased inheritance.
PLoS Genetics · Jun 24, 2025Peer-reviewedGenetics