Дмитрий Алексеевич Кнорре

The paper investigates how mtDNA deletion variants (rho-) outcompete wild-type mtDNA (rho+) in yeast, finding higher copy numbers and intracellular fitness advantage contribute to biased inheritance.

This study examines the rapid divergence of male and female mitochondrial genomes in Yoldia hyperborea, revealing novel genes and structural changes associated with doubly uniparental inheritance.

The paper investigates the role of mitochondrial DNA repeats in aging and healthspan, finding that disrupting the common repeat reduces somatic deletions and improves healthspan.

The paper analyzes the mitochondrial mutation spectrum in chordates, identifying three main mutation signatures and their underlying causes, with implications for age-related disease prevention.

The paper identifies a contact zone in the human mitochondrial genome where deletions are more likely, linking it to aging and lifespan.

The paper identifies an AH>GH substitution signature in mtDNA linked to aging and TSSS, showing higher frequency in species with longer generation lengths.