Melvin E. Andersen

This study investigates TCDD-induced wasting in rats using transcriptomics, showing AHR and ARNT involvement in circadian disruption and metabolic gene downregulation at high doses.

This study identifies pathway perturbations in liver caused by PFAS exposure, showing longer-chain PFAS downregulate lipid and steroid metabolism genes, similar to TCDD, suggesting a common MOA involving PPAR inhibition.

The paper develops predictive models to identify tissue-specific AhR binding determinants using machine learning on genomic features.

The paper maps the AHR-mediated gene regulatory network in mouse liver using gene expression and TF binding data, showing distinct expression patterns and biological process enrichments among AHR-bound and unbound genes.