Joshua Harrill

This study evaluates transcriptomic and morphological profiling methods for hazard assessment using reference chemicals in renal cells, finding HTTr provides higher mechanistic resolution than CPP.

This study uses Cell Painting PLUS to identify nephrotoxicity-related morphological signatures in human RPTEC/TERT1 cells by analyzing over 300 compounds.

Cell Painting in primary human hepatocytes exposed to 1,085 compounds detects bioactivity at lower concentrations than cytotoxicity assays and predicts cell-based, but not cell-free, ToxCast endpoints across feature extractors.

This study investigates TCDD-induced wasting in rats using transcriptomics, showing AHR and ARNT involvement in circadian disruption and metabolic gene downregulation at high doses.