Plasmin-Mediated Processing of Clumping Factor A Impacts Bacterial, Aggregation and Abscess Formation during Staphylococcus aureus Infection
Mary B. Turley, Zhicheng Hu, Ross W. Ward, Ed C. Lavelle, Tao Jin, Joan A. Geoghegan
This study shows plasmin cleaves ClfA, disrupting fibrinogen binding and enhancing S. aureus virulence and abscess formation.
bioRxiv · Jun 30, 2025 · PreprintMicrobiology