DZNep-induced single point mutation (M236I) in poxviral 2'-O-methyltransferase enhances mRNA stability and translation efficiency
Assim Verma, Ram Kumar, Himanshu Kamboj, Garvit Kumar, Virendra Kumar Meena, Vikas Sharma, Tarun Kumar Bhattacharaya, Bhupendra Nath Tripathi, Shalini Sharma, Naveen Kumar
The paper shows that a mutation in poxviral VP39 enhances mRNA stability and translation efficiency by bypassing feedback inhibition.
bioRxiv · Mar 10, 2025 · PreprintMicrobiology