Shalaw R. Sallah

This study predicts pH-sensing histidine residues in the human proteome using amino acid conservation, structural context, and benchmarking with known pH-sensors.

The paper predicts pH-dependent sites in the human proteome, finding enrichment in cell adhesion proteins and shielding of ribosomal/nuclear processes from pH fluctuations.

The paper investigates missense somatic mutations in cancer, focusing on pH-dependence and proteostasis, and finds no clear separation of mutation subsets by pH-sensing potential.

The paper investigates the association between gene expression variability and incomplete penetrance in inherited eye disorders using genomic and transcriptomic data.