Simon C. Lovell

Domain-specific mechanisms of YAP1 variants in ocular coloboma revealed by in-vitro and organoid studies

The paper investigates YAP1 variants' role in ocular coloboma using in vitro and organoid studies, showing how missense variants affect YAP1-TEAD binding and transcriptional activity.

Structural constraints acting on the SARS-CoV-2 spike protein reveal limited space for viral adaptation

This study analyzes structural constraints on the SARS-CoV-2 spike protein and finds limited change in constraint despite phenotypic evolution and no reduction in accessible substitutions over time.

Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages

The paper shows CRISPR immunity in Pseudomonas aeruginosa varies in fitness benefit against virulent phages, depending on the likelihood of evolving receptor-based resistance through spontaneous mutations.

Evolutionary potential of the Escherichia coli antimutator ΔnudJ is reduced via altered mutational spectrum

This study examines how the antimutator ΔnudJ in Escherichia coli reduces mutation rate and alters mutational spectrum, leading to decreased antibiotic resistance potential.

From a single sequence to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2 protein sequences

This paper shows that protein language models can assess mutation effects in SARS-CoV-2 spike protein without multiple sequence alignments, capturing evolutionary constraints and variant properties.

Variability in gene expression is associated with incomplete penetrance in inherited eye disorders

The paper investigates the association between gene expression variability and incomplete penetrance in inherited eye disorders using genomic and transcriptomic data.