Author

Edwin H. Yau

Roswell Park Comprehensive Cancer CenterORCID 0000-0002-3972-0756Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Agnieszka Katarzyna WitkiewicziD· 1 shared Erik S. KnudseniD· 1 shared Ethan V. AbeliD· 1 shared Jianxin WangiD· 1 shared Vishnu Muthuraj KumarasamyiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

Agnieszka Katarzyna WitkiewiczORCID

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1 paper

Recent·Most cited

Targeting Distinct Cell Cycle Nodes Overcomes KRAS/RAS Inhibitor Resistance

Vishnu Muthuraj Kumarasamy, Jianxin Wang, Edwin H. Yau, Ethan V. Abel, Agnieszka Katarzyna Witkiewicz, Erik S. Knudsen

This study identifies sustained cell cycle activity as a mechanism of resistance to KRAS inhibitors and shows that co-targeting cell cycle nodes with CDK4/6 or CDK2 restores sensitivity and provides durable tumor control.

Cancer Research · Oct 2, 2026Peer-reviewedCancer Biology