A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response in human cells
Jean-François Lemay, Edlie St-Hilaire, Sari Gezzar-Dandashi, Mary E. McQuaid, Daryl A. Ronato, Yuandi Gao, François Bélanger, Christina Sawchyn, Aimé Boris Kimenyi Ishimwe, Frédérick A. Mallette, Jean‐Yves Masson, Elliot A. Drobetsky, Hugo Würtele
The paper identifies SCAI as a novel regulator that modulates the UV-induced replicative stress response by inhibiting EXO1 activity and preventing excessive RPA-ssDNA accumulation.
bioRxiv · Jan 17, 2022 · PreprintMolecular Biology