GenomicsbioRxivPreprint
Methylation-mediated retuning on the enhancer-to-silencer activity scale of networked regulatory elements guides driver-gene misregulation
Yifat Edrei, RobertD. Levy, Anat Marom…·Asaf Hellman
The paper identifies epigenetic retuning of enhancer-silencer networks as a major cause of driver-gene misregulation in cancer, revealing its dominance over coding and regulatory mutations.
2 citations