Author

Asaf Hellman

Hebrew University of JerusalemORCID 0000-0002-5252-6894Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:human· 1

Frequent Co-Authors

Yifat EdreiiD· 2 shared Anat MaromiD· 1 shared Bernhard RadlwimmeriD· 1 shared RobertD. LevyiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersGenomics

Yifat EdreiORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintJul 3, 2024

On the enigmatic null effect of global methylation perturbation

Yifat Edrei, Asaf Hellman

The paper resolves the paradox of global methylation perturbation having little effect on most genes by showing gene-specific protection through enhancer-silencer balance.

DOI 10.1101/2024.07.03.601377

DNA methylationstatistical model

𝕏 PostBluesky

GenomicsbioRxivPreprintMar 2, 2021

Methylation-mediated retuning on the enhancer-to-silencer activity scale of networked regulatory elements guides driver-gene misregulation

Yifat Edrei, RobertD. Levy, Anat Marom…·Asaf Hellman

The paper identifies epigenetic retuning of enhancer-silencer networks as a major cause of driver-gene misregulation in cancer, revealing its dominance over coding and regulatory mutations.

2 citations

humanDNA methylation

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