Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer’s disease
Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wüster, Manav Kapoor, Yonglian Sun, Sharookh B. Kapadia, Lino C. Gonzalez, Ali A. Zarrin, Alison Goate, David Hansen, Timothy W. Behrens, Robert Graham
The paper identifies a PILRA variant that reduces ligand binding and HSV-1 infection, potentially protecting against Alzheimer’s disease.
PLoS Genetics · Nov 2, 2018Peer-reviewedGenetics