Sharookh B. Kapadia

Scoring gene importance by interpreting single-cell foundation models

The paper introduces SIGnature, a framework for scoring gene importance using attributions from scRNA-seq foundation models, and demonstrates its utility in identifying novel associations of the MS1 signature with hyperinflammatory conditions.

G-CSF and IL-6 drive myeloid dysregulation during severe viral infection

This study identifies G-CSF and IL-6 as drivers of myeloid dysregulation during severe viral infection, showing their role in emergency myelopoiesis and tissue injury.

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer’s disease

The paper identifies a PILRA variant that reduces ligand binding and HSV-1 infection, potentially protecting against Alzheimer’s disease.