Binding of different substrate molecules at the docking site and the active site of γ-secretase can trigger toxic events in sporadic and familial Alzheimer's disease
Željko M. Svedružić, Vesna Šendula Jengić, Lucija Ostojić
The paper shows that γ-secretase saturation with substrates leads to toxic effects in Alzheimer's disease by disrupting presenilin structures and increasing Aβ-protein production.
International Journal of Molecular Sciences · Jan 17, 2023Peer-reviewedNeuroscience