The TREM2-R47H Variant Drives Alzheimer's-Relevant Alterations in Forebrain Organoids Beyond Microglial Populations
Aigerim S. Kamzina, Kate E Leinenweber, Fabrizio Ecca, A. Aldabergenova, Matthew J. Huentelman
This study shows that the TREM2-R47H variant causes neurodegenerative changes in forebrain organoids and impairs cell integration into the microglial niche.
bioRxiv · May 3, 2026 · PreprintNeuroscience