NeurosciencebioRxivPreprint
The TREM2-R47H Variant Drives Alzheimer's-Relevant Alterations in Forebrain Organoids Beyond Microglial Populations
Aigerim S. Kamzina, Kate E Leinenweber, Fabrizio Ecca…·Matthew J. Huentelman
This study shows that the TREM2-R47H variant causes neurodegenerative changes in forebrain organoids and impairs cell integration into the microglial niche.